On April 12, 2021, the Holy Father Francis, upon the proposal of His Excellency Msgr. Vincenzo Paglia, President of the Pontifical Academy for Life, established the renAIssance Foundation, with public canonical juridical personality. The renAIssance Foundation is located in the Vatican City State, at the Pontifical Academy for Life, and is an instrumental entity of that Academy.

To achieve these goals, the renAIssance Foundation aims to promote, among people qualified for their scientific, ecclesial, cultural, entrepreneurial and professional commitment in society, an anthropological and ethical reflection on artificial intelligence and new technologies; to encourage scientific initiatives and collaboration with International Bodies, Sovereign States, universities, research centers, private and public companies that develop activities, services and studies in the field of artificial intelligence to disseminate the Rome Call for AI Ethics; to promote fundraising to support these activities.